16+
Оглавление - General system theory of aging
Special role of the immune system
- Introduction
- Main Points
- Chapter 1. Methodology and principles of studying the aging phenomenon
- 1.1. The main methodological errors, myths, and cliches in the general analysis of the problem of aging
- 1.2. History of views on the aging process
- 1.3. Methodology of knowledge: three stages, three paradigms
- 1.4. Features of the system approach as a modern universal scientific method of problem analysis
- 1.4.1. Using a systematic approach to analyze оf aging process
- 1.4.2. General methodology about the cause of phenomena
- 1.4.3. Aging Hierarchy
- 1.5. Essential modeling — the basis of understanding the phenomenon of aging
- Chapter 2. Theoretical approaches to the study of aging phenomenon
- 2.1. Essential definition and cause of aging
- 2.2. Chaos and order processes, entropy and energy
- 2.3. The basic formula and the basic law of aging
- 2.4. Basic global mechanisms: types of aging
- 2.4.1. The main common mechanisms are types of aging
- 2.4.2. Stochastic dependent death non-elements of the system
- 2.4.3. Stochastic dependent cumulative mechanism of aging
- 2.4.4. Regulatory aging
- 2.4.5. The relationship of the main mechanisms of aging
- Chapter 3. Modeling the phenomenon and mechanisms of aging
- 3.1. Mechanical model of system aging
- 3.1.1. An example of a mechanical model of aging systems
- 3.1.2. From mechanical to a biological system
- 3.2. Modeling of global aging mechanisms
- 3.2.1. Simulation of stochastic-dependent system “pollution”
- 3.2.2. Simulation of stochastic-dependent death of non-recovering system elements
- 3.2.3. Regulatory aging modeling
- 3.2.4. Obtaining an analogue of the Gompertz-Makema formula from the regulatory model of aging
- 3.2.5. Modeling the interaction of the three fundamental mechanisms of aging
- 3.3. Unified Systems Theory of Aging
- 3.4. A systematic approach to the diagnosis of aging
- 3.4.1. Fundamentals of the diagnosis of aging
- 3.4.2. Estimation of the rate of aging according to the graphs of the intensity of mortality
- 3.4.3. Does it exist a correlation of Strehler-Mildwan?
- 3.4.4. Mortality as an indicator of aging: opportunities and limitations
- 3.4.5. Individual diagnosis of aging — biological age
- 3.4.6. Artificial intelligence capabilities for analyzing human biomarkers
- 3.4.7. Diagnosis of syndromes and manifestations of aging
- 3.5. Systematic approach and ways of influencing aging
- 3.5.1. Fundamental causes of aging and general routes of exposure
- 3.5.2. Aging syndromes, their diagnosis and ways of correction
- 3.5.3. Types of metabolic disorders
- 3.5.4. Geroprotectors — special anti-age medicine
- 3.5.5. Elements of tactics in the diagnosis of aging
- 3.6. Whether the treatment of age-related diseases anti-aging therapy
- Chapter 4. The regulatory theory of aging as the main mechanism for the aging of biological systems
- 4.1. Some examples from evolutionary biology
- 4.2. Age-related cell degeneration as the basis of aging
- 4.3. Ways to restore regulatory programs
- 4.4. Practical approaches to life extension
- Chapter 5. Self-organization of growing cellular systems and the integrative role of the immune system
- 5.1. Self-organization of cellular systems — the basis of the formation of the body
- 5.1.1. Regulation of proliferation of single-type cells (Chalons)
- 5.1.2. “Cell hypercycle” — the basis of self-regulation and self-sustaining multicellular organism
- 5.1.3. The evolution of the cell hypercycle
- 5.1.4. Functioning of the cell hypercycle
- 5.2. T lymphocytes — growth regulators of somatic cells
- 5.2.1. Data on the regulation of lymphocyte growth of somatic cells
- 5.2.2. Specialized cellular system for regulating the growth of somatic tissues
- 5.2.3 Properties of lymphocyte growth regulators cells
- 5.2.4. The new concept of the emergence of immunity
- Chapter 6. A New Immuno-Regulatory Theory of Aging
- 6.1. Changes in the immune system during aging
- 6.2. New immuno-regulatory theory of aging
- 6.3. Prospects for immuno-correction of aging
- 6.3.1. Study of lymphocyte regulators of the cell growth experiment
- 6.3.2. Influence of an immunomodulator Transfer factor on aging
- Conclusion
- Appendix
- References